Hilton Prize Coalition [to 12 March 2016]

Hilton Prize Coalition [to 12 March 2016]
http://prizecoalition.charity.org/
An Alliance of Hilton Prize Recipients

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Empowering Women through Collaboration
Posted March 11, 2016 ·
International Women’s Day, inaugurated in the early 1900s, celebrates the social, economic, cultural and political achievements of women. This year’s theme, #PledgeforParity, stems from the World Economic Forum’s 2015 Global Gender Gap Report, which states that the gender gap won’t close entirely until the year 2133. International Women’s Day has grown into a movement (#IWD2016) that brings men and women together annually on March 8th to discuss women’s achievements and the progress that still needs to be made.

Below we highlight three of the Hilton Prize Coalition member organizations working to advance women’s rights through their programs and partnerships around the world [Amref Health Africa, BRAC, Landesa]…

Center for Global Development [to 12 March 2016]

Center for Global Development [to 12 March 2016]
http://www.cgdev.org/page/press-center
Selected Press Releases, Blog Posts, Publications

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Anti-Corruption Strategies in Foreign Aid: From Controls to Results
3/7/16
William Savedoff
Corruption is an obstacle to social and economic progress in developing countries yet we still know very little about the effectiveness of anti-corruption efforts and their impact on development impact. This essay looks at 25 years of efforts by foreign aid agencies to combat corruption and proposes a new strategy which could leverage existing approaches by directly incorporating information on development results.

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Do the Results Match the Rhetoric? An Examination of World Bank Gender Projects
3/7/16
Charles Kenny and Megan O’Donnell
This paper seeks to determine the degree to which a gender lens has been incorporated into World Bank projects and the success of individual projects according to gender equality-related indicators.

World Economic Forum [to 12 March 2016]

World Economic Forum [to 12 March 2016]
https://agenda.weforum.org/news/

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News 8 Mar 2016
Helping Africa to Unleash its Digital Potential
:: High-level meeting held in Morocco to discuss ways to develop Africa’s digital economy
:: Access to internet, skill development and lower hurdles for entrepreneurship seen as key
:: Future meetings to boost Africa’s digital economy to be held in Mombasa, Kenya, and Kigali, Rwanda

Conrad N. Hilton Foundation [to 12 March 2016]

Conrad N. Hilton Foundation [to 12 March 2016]
http://www.hiltonfoundation.org/news

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Our News
A Tribute to William H. Foege, M.D., M.P.H.
March 10, 2016
After eight years of service, William H. Foege, M.D., M.P.H., has retired from the Conrad N. Hilton Foundation board of directors. Dr. Foege previously served for seven years on the prestigious international jury of the Conrad N. Hilton Humanitarian Prize, the world’s largest humanitarian award.

Dr. Foege is a world renowned epidemiologist who worked in the successful campaign to eradicate smallpox in the 1970s. Dr. Foege became Chief of the CDC Smallpox Eradication Program and was appointed Director of the U.S. Centers for Disease Control in 1977.

In 1984, Dr. Foege and several colleagues formed the Task Force for Child Survival, a working group for the World Health Organization, UNICEF, The World Bank, the United Nations Development Programme, and the Rockefeller Foundation. Its success in accelerating childhood immunization led to an expansion of its mandate in 1991 to include other issues which diminish the quality of life for children.

Dr. Foege has championed many issues, but child survival and development, injury prevention, population, preventive medicine, and public health leadership are of special interest, particularly in the developing world. He is a strong proponent of disease eradication and control, and has taken an active role in the eradication of Guinea worm, polio and measles, and the elimination of River Blindness. By writing and lecturing extensively, Dr. Foege has succeeded in broadening public awareness of these issues and bringing them to the forefront of domestic and international health policies.

Dr. Foege received the Presidential Medal of Freedom in 2012, in addition to many other awards during the course of his career. He also holds honorary degrees from numerous institutions, and was named a Fellow of the London School of Tropical Medicine and Hygiene in 1997. He is the author of more than 125 professional publications.

It is with profound gratitude that we thank Dr. Foege for his exemplary service on the Hilton Foundation board. We were fortunate to benefit from both his broad vision of life as well as his deep knowledge of the health field. His personal style motivated others to want to engage and explore issues further. While we are sad to be losing an influential and prominent member of our board, we remain grateful that Dr. Foege raised the bar of our deliberations. We wish him all the best in his future endeavors.
Steven M. Hilton
Chairman of the Board
Conrad N. Hilton Foundation

MacArthur Foundation [to 12 March 2016]

MacArthur Foundation [to 12 March 2016]
http://www.macfound.org/

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Publication
Assessing the Impacts of State Immigration Policies
Published March 9, 2016
Nearly all states have implemented immigration-related reform in the past 15 years, according to a report by the RAND Corporation, a MacArthur grantee. The report takes stock of states’ immigration legislation – ranging from employment on unauthorized immigrants to making drivers licenses available regardless of immigration status – and provides a cost-benefit framework to help policymakers assess the impacts of those policies.

Pew Charitable Trusts [to 12 March 2016]

Pew Charitable Trusts [to 12 March 2016]
http://www.pewtrusts.org/en/about/news-room/press-releases

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Press Release
Pew: Major Deficiencies in Monitoring of Chemical Residues in Meat, Poultry
March 08, 2016 Safe Food Project
WASHINGTON—A federal program meant to protect consumers from tainted meat, poultry, and egg products needs greater scientific rigor and transparency, according to a report from The Pew Charitable Trusts released today. The analysis shows that the National Residue Program (NRP) does not routinely test for several compounds, such as dioxins and certain heavy metals, that are widely recognized as posing a significant public health risk. The analysis also finds that the NRP lacks clear processes for incorporating new research and responding to emerging contamination threats.

The report, The National Residue Program for Meat, Poultry, and Egg Products: An Evaluation, details how the program selects the drugs, pesticides, and environmental contaminants to monitor and how it documents the results of its sampling and testing…

Rockefeller Foundation [to 12 March 2016]

Rockefeller Foundation [to 12 March 2016]
http://www.rockefellerfoundation.org/newsroom

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March 8, 2016
The Rockefeller Foundation and OMC Power Reach a US$4.5 Million Deal to Finance 100 mini-grids in Rural India
NEW YORK, UNITED STATES/DELHI, INDIA—The Rockefeller Foundation and OMC Power have reached a US$4.5 million deal to finance OMC Power’s construction and retrofitting of 100 solar power plants with mini-grids, in rural Uttar Pradesh…

Robert Wood Johnson Foundation [to 12 March 2016]

Robert Wood Johnson Foundation [to 12 March 2016]
http://www.rwjf.org/en/about-rwjf/newsroom/news-releases.html

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March 11, 2016
RWJF Launches Leadership Development Programs
RWJF has launched four new leadership development programs that engage people who work across a variety of sectors to challenge the status quo and build a Culture of Health in the United States.

March 11, 2016
Statement from RWJF on CVS Health’s Anti-Tobacco Campaign
RWJF commends CVS Health for its decision to spend $50 million over the next five years to help create a tobacco-free nation.

March 10, 2016
RWJF Statement on the Passing of Ralph Larsen, Former Foundation Trustee
RWJF mourns Ralph Larsen, former Foundation Trustee and Former Chairman of the Board and CEO of Johnson and Johnson who died on March 9, 2016, in Florida. He was 77 years old.

BMC Health Services Research (Accessed 12 March 2016)

BMC Health Services Research
http://www.biomedcentral.com/bmchealthservres/content
(Accessed 12 March 2016)

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Research article
Scoping review of complexity theory in health services research
There are calls for better application of theory in health services research. Research exploring knowledge translation and interprofessional collaboration are two examples, and in both areas, complexity theory…
David S. Thompson, Xavier Fazio, Erika Kustra, Linda Patrick and Darren Stanley
BMC Health Services Research 2016 16:87
Published on: 12 March 2016

BMC Infectious Diseases (Accessed 12 March 2016)

BMC Infectious Diseases
http://www.biomedcentral.com/bmcinfectdis/content
(Accessed 12 March 2016)

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Review
Does tuberculosis threaten our ageing populations?
The global population is ageing quickly and our understanding of age-related changes in the immune system suggest that the elderly will have less immunological protection from active tuberculosis (TB).
Rachel Byng-Maddick and Mahdad Noursadeghi
BMC Infectious Diseases 2016 16:119
Published on: 11 March 2016

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Study protocol
Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries
The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year…
Thomas Jaenisch, Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh, Sophie Yacoub, Ngoun Chanpheaktra, Varun Kumar, Lucy Lum Chai See, Jameela Sathar, Ernesto Pleités Sandoval, Gabriela Maria Marón Alfaro, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker…
BMC Infectious Diseases 2016 16:120
Published on: 11 March 2016

BMC Pregnancy and Childbirth (Accessed 12 March 2016)

BMC Pregnancy and Childbirth
http://www.biomedcentral.com/bmcpregnancychildbirth/content
(Accessed 12 March 2016)

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Debate
Millennium development Goal 5: progress and challenges in reducing maternal deaths in Ghana
Minerva Kyei-Nimakoh, Mary Carolan-Olah and Terence V. McCann
Published on: 9 March 2016

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Research article
Factors influencing women’s preference for health facility deliveries in Jharkhand state, India: a cross sectional analysis
Sanghita Bhattacharyya, Aradhana Srivastava, Reetabrata Roy and Bilal I. Avan
Published on: 7 March 2016

BMC Public Health (Accessed 12 March 2016)

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 12 March 2016)

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Research article
A survey of the governance capacity of national public health associations to enhance population health
James Chauvin, Mahesh Shukla, James Rice and Laetitia Rispel
BMC Public Health 2016 16:251
Published on: 11 March 2016
Abstract
Background
National public health associations (PHAs) are key partners with governments and communities to improve, protect and promote the public’s health. Governance and organizational capacity are among the key determinants of a PHA’s effectiveness as an advocate for appropriate public health policies and practice.
Methods
During 2014, the World Federation of Public Health Associations (WFPHA) conducted an on-line survey of its 82 PHA members, to identify the state of organizational governance of national public health associations, as well as the factors that influence optimal organizational governance. The survey consisted of 13 questions and focused on the main elements of organizational governance: cultivating accountability; engaging stakeholders; setting shared direction; stewarding resources; and, continuous governance enhancement. Four questions included a qualitative open-ended response for additional comments. The survey data were analyzed using Microsoft Excel. The qualitative data was analyzed using thematic content analysis
Results
Responses were received from 62 PHAs, constituting a 75.6 % response rate. The two most important factors that support governance effectiveness were a high degree of integrity and ethical behavior of the PHA’s leaders (77 %) and the competence of people serving on the PHA’s governing body (76 %). The lack of financial resources was considered as the most important factor that negatively affected organizational governance effectiveness (73 %). The lack of mentoring for future PHA leaders; ineffective or incompetent leadership; lack of understanding about good governance practices; and lack of accurate information for strategic planning were identified as factors influencing PHA governance effectiveness. Critical elements for PHA sustainability included diversity, gender-responsiveness and inclusive governance practices, and strategies to build the future generation of public health leaders.
Conclusion
National PHA have a responsibility to put into place the practices and infrastructure that enhance organizational governance. This will enhance their ability to be effective advocates for policies and practices that enhance, protect and promote the public’s health. The WFPHA has an important role to play in providing the technical assistance and financial resources to assist PHAs in attaining and sustaining a higher level of governance capacity.

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Research article
Integrating acute malnutrition interventions into national health systems: lessons from Niger
Since 2007, integrated care of acute malnutrition has been promoted in Niger, a country affected by high burden of disease. This policy change aimed at strengthening capacity and ownership to manage the condition…
Hedwig Deconinck, Mahaman Hallarou, Bart Criel, Philippe Donnen and Jean Macq
BMC Public Health 2016 16:249
Published on: 10 March 2016

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Research article
Influence of internal migration on reproductive health in Myanmar: results from a recent cross-sectional survey
Maternal and reproductive health remains a significant public health issue in Myanmar. Little data exists on women’s health issues, including social and demographic influences.
May Sudhinaraset, Nadia Diamond-Smith, May Me Thet and Tin Aung
BMC Public Health 2016 16:246
Published on: 9 March 2016

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Research article
Maternal knowledge, outcome expectancies and normative beliefs as determinants of cessation of exclusive breastfeeding: a cross-sectional study in rural Kenya
Despite the importance of multiple psychosocial factors on nutrition-related behavior, very few studies have explored beyond the role of mothers’ knowledge and perception of child-focused outcomes on the duration…
Constance A. Gewa and Joan Chepkemboi
BMC Public Health 2016 16:243
Published on: 9 March 2016

Retrospective analysis of reproductive health indicators in the United Nations High Commissioner for Refugees post-emergency camps 2007–2013

Conflict and Health
http://www.conflictandhealth.com/
[Accessed 12 March 2016]

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Research
Retrospective analysis of reproductive health indicators in the United Nations High Commissioner for Refugees post-emergency camps 2007–2013
Jennifer Whitmill, Curtis Blanton, Sathyanarayanan Doraiswamy, Nadine Cornier, Marian Schilperood, Paul Spiegel and Barbara Tomczyk
Published on: 9 March 2016
Abstract
Background
The United Nations Refugee Agency’s Health Information System issues analytical reports on the current camp conditions and trends for priority reproductive health issues. The goal was to assess the status of reproductive health by analyzing seven indicators and comparing them to standards and host country estimates.
Methods
Data on seven indicators were extracted from the database during a seven-year period (2007 through 2013). A standardized country inclusion criterion was created based on the year of country implementation and the percentage of missing reports per camp and year. The unit of analysis was monthly camp reports by year within a country. To account for the lack of independence of monthly camp reports, the variance was computed using Taylor Series Linearization methods in SAS.
Results
Ten of the 23 eligible countries met the inclusion criterion. The mean camp maternal and neonatal mortality rates, except for two country years, were lower than the host country estimates for all countries and years. There was a significant increase in the percent of births attended by a skilled birth attendant (p <0.0001), and 8 of 10 countries did not meet the standard of 100 % for all reporting years. The percent of births performed by Caesarian section (p<0.001), were below the recommended minimum standard for nearly half of the countries every year. There was a significant increase in the percent of women screened for syphilis across years (p<0.0001) and the percent of women who received post HIV exposure prophylaxis (p<0.0001) and 10 % reached the standard for all reporting years, respectively.
Conclusion
Comprehensive, consistent and comparable statistics on reproductive health provides an opportunity to assess progress towards indicator standards. Despite some improvements over time, this analysis confirms that most countries did not meet standards and that there were differences in reproductive health indicators between countries and across years. Consequently, the HIS periodic monitoring of key reproductive health indicators at the camp level should continue. Data should be used to improve intervention strategies.

Disasters – April 2016

Disasters
April 2016 Volume 40, Issue 2 Pages 183–383
http://onlinelibrary.wiley.com/doi/10.1111/disa.2016.40.issue-2/issuetoc

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Papers
The professional humanitarian and the downsides of professionalisation
Eric James*
Article first published online: 17 AUG 2015
DOI: 10.1111/disa.12140
Abstract
Criticisms lodged at humanitarian relief often include the belief that professionalisation is needed. The problems associated with humanitarianism would end, it is assumed, if the delivery of aid, and relief workers themselves, were more professional and ‘business like’. To explore this further, the paper asks what comprises a profession, and offers four criteria: 1) specialisation of knowledge; 2) establishment of the profession as a livelihood; 3) organisation and institutionalisation; and 4) legitimacy and authority. A model for understanding professionalisation, as developed by the author, is then presented. The analysis compares six other professions against the same criteria to argue that the humanitarian community already constitutes a profession. Finally, three potential downsides of professionalisation are offered: the distance of the relief worker from the beneficiary, barriers to entry into the humanitarian sector, and adding to risk aversion and a decline in innovation. Based on these findings, professionalisation should be approached with some caution.

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Papers
Livelihoods, conflict and aid programming: is the evidence base good enough? (pages 226–245)
Richard Mallett and Rachel Slater
Article first published online: 17 AUG 2015 | DOI: 10.1111/disa.12142
Abstract
In conflict-affected situations, aid-funded livelihood interventions are often tasked with a dual imperative: to generate material welfare benefits and to contribute to peacebuilding outcomes. There may be some logic to such a transformative agenda, but does the reality square with the rhetoric? Through a review of the effectiveness of a range of livelihood promotion interventions—from job creation to microfinance—this paper finds that high quality empirical evidence is hard to come by in conflict-affected situations. Many evaluations appear to conflate outputs with impacts and numerous studies fail to include adequate information on their methodologies and datasets, making it difficult to appraise the reliability of their conclusions. Given the primary purpose of this literature—to provide policy guidance on effective ways to promote livelihoods—this silence is particularly concerning. As such, there is a strong case to be made for a restrained and nuanced handling of such interventions in conflict-affected settings

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Papers
Country logistics performance and disaster impact (pages 262–283)
Alain Vaillancourt and Ira Haavisto
Article first published online: 17 AUG 2015 | DOI: 10.1111/disa.12146
Abstract
The aim of this paper is to deepen the understanding of the relationship between country logistics performance and disaster impact. The relationship is analysed through correlation analysis and regression models for 117 countries for the years 2007 to 2012 with disaster impact variables from the International Disaster Database (EM-DAT) and logistics performance indicators from the World Bank. The results show a significant relationship between country logistics performance and disaster impact overall and for five out of six specific logistic performance indicators. These specific indicators were further used to explore the relationship between country logistic performance and disaster impact for three specific disaster types (epidemic, flood and storm). The findings enhance the understanding of the role of logistics in a humanitarian context with empirical evidence of the importance of country logistics performance in disaster response operations.

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Papers
Arts as a vehicle for community building and post-disaster development (pages 284–303)
Ephrat Huss, Roni Kaufman, Amos Avgar and Eitan Shuker
Article first published online: 17 AUG 2015 | DOI: 10.1111/disa.12143
Abstract
Use of the arts in international aid is common in an ad hoc form, but it has not been systematically theorised or evaluated. The arts have the potential to be a culturally contextualised and sustainable intervention for adults and children in the aftermath of war or disaster. On the micro level, the arts are a method to enable the retrieval and reprocessing of traumatic memories that are often encoded in images rather than in words. On a macro level, they can help to reconstruct a group narrative of a disaster as well as mobilise people back into control of their lives. This paper researches a long-term project using arts in Sri Lanka following the civil war and tsunami. A central finding is the need to understand arts within their cultural context, and their usefulness in strengthening the voices and problem-solving capacities of the victims of the disaster.

Eurosurveillance – Volume 21, Issue 10, 10 March 2016

Eurosurveillance
Volume 21, Issue 10, 10 March 2016
http://www.eurosurveillance.org/Public/Articles/Archives.aspx?PublicationId=11678

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Rapid communications
Profile of illness in Syrian refugees: A GeoSentinel analysis, 2013 to 2015
by F Mockenhaupt, K Barbre, M Jensenius, C Larsen, E Barnett, W Stauffer, C Rothe, H Asgeirsson, D Hamer, D Esposito, P Gautret, P Schlagenhauf
Abstract
Screening of 488 Syrian unaccompanied minor refugees (< 18 years-old) in Berlin showed low prevalence of intestinal parasites (Giardia, 7%), positive schistosomiasis serology (1.4%) and absence of hepatitis B. Among 44 ill adult Syrian refugees examined at GeoSentinel clinics worldwide, cutaneous leishmaniasis affected one in three patients; other noteworthy infections were active tuberculosis (11%) and chronic hepatitis B or C (9%). These data can contribute to evidence-based guidelines for infectious disease screening of Syrian refugees.

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Research Articles
Children and young people with perinatal HIV in Europe: epidemiological situation in 2014 and implications for the future
by Writing group for the Kids to Adults Working Group and Data Management and Harmonisation Group in EuroCoord

Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective

Infectious Diseases of Poverty
http://www.idpjournal.com/content
[Accessed 12 March 2016]

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Scoping Review
Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective
Om Prakash Singh, Bhawana Singh, Jaya Chakravarty and Shyam Sundar
Published on: 8 March 2016
Abstract
Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality and major disability in the Indian subcontinent. It is most neglected tropical disease, particularly in terms of new drug development for the lack of financial returns. An elimination campaign has been running in India since 2005 that aim to reduce the incidence of VL to below 1 per 10,000 people at sub-district level. One of the major components in this endeavor is reducing transmission through early case detection followed by complete treatment. Substantial progress has been made during the recent years in the area of VL treatment, and the VL elimination initiatives have already saved many lives by deploying them effectively in the endemic areas. However, many challenges remain to be overcome including availability of drugs, cost of treatment (drugs and hospitalization), efficacy, adverse effects, and growing parasite resistance. Therefore, better emphasis on implementation research is urgently needed to determine how best to deliver existing interventions with available anti-leishmanial drugs. It is essential that the new treatment options become truly accessible, not simply available in endemic areas so that they may promote healing and save lives. In this review, we highlight the recent advancement and challenges in current treatment options for VL in disease endemic area, and discuss the possible strategies to improve the therapeutic outcome.

International Journal of Infectious Diseases – March 2016 [HIV]

International Journal of Infectious Diseases
March 2016 Volume 44, p1-74
http://www.ijidonline.com/current

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Editorial
HIV in the MENA Region: Cultural and Political Challenges
Seif Al-Abri, Jacques E. Mokhbat
p64–65
Published online: February 9 2016
Preview
Over the last few years, our knowledge of the HIV epidemic and its drivers in the Middle East and North Africa (MENA) region have improved markedly, thanks to many recently conducted studies.1 While the annual number of new HIV infections in sub-Saharan Africa has declined by 33% since 2005, new HIV infections in the MENA region have increased by 31% since 2001, the greatest increase in all regions in the world. There are growing HIV epidemics in key populations (KPs) including people who inject drugs, men who have sex with men, and to a lesser extent, female sex workers.

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Reviews
Rapid Spread of Zika Virus in The Americas – Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games
Eskild Petersen, Mary E. Wilson, Sok Touch, Brian McCloskey, Peter Mwaba, Matthew Bates, Osman Dar, Frank Mattes, Mike Kidd, Giuseppe Ippolito, Esam I. Azhar, Alimuddin Zumla
p11–15
Published online: February 4 2016
Highlights
:: We discuss the global spread of the Zika virus (ZIKV) since its first discovery in 1947 in Uganda to the current outbreak in the Americas which has been declared a ‘Global emergency’ by the World Health Organization.
:: We highlight that ZIKV and other arboviruses may pose a threat to the attendees of the 2016 Rio De Janeiro Olympic and Paralympic games and to residents of Brazil.
:: We review clinical features and highlight the need for more accurate and rapid screening tests for ZIKV
:: We discuss the recent possible linkage of microcephaly in babies exposed to ZIKV in utero, and highlight knowledge gaps in the epidemiology and pathogenesis of ZIKV.
:: We review the public health implications of the current ZIKV outbreak and highlight the need for enhanced preparedness and proactive surveillance for all infectious diseases before, during and after the 2016 Olympic games.
:: We stress that there is no specific treatment available or preventive vaccines and that that the emergence of ZIKV soon after the Ebola outbreak, is yet another wake up call for the urgent need for a coordinated global response for prevention and spread of infectious diseases with epidemic potential at mass gatherings events
Summary
Mass gatherings at major international sporting events put millions of international travelers and local host-country residents at risk of acquiring infectious diseases, including locally endemic infectious diseases. The mosquito-borne Zika virus (ZIKV) has recently aroused global attention due to its rapid spread since its first detection in May 2015 in Brazil to 22 other countries and other territories in the Americas. The ZIKV outbreak in Brazil, has also been associated with a significant rise in the number of babies born with microcephaly and neurological disorders, and has been declared a ‘Global Emergency by the World Health Organization. This explosive spread of ZIKV in Brazil poses challenges for public health preparedness and surveillance for the Olympics and Paralympics which are due to be held in Rio De Janeiro in August, 2016. We review the epidemiology and clinical features of the current ZIKV outbreak in Brazil, highlight knowledge gaps, and review the public health implications of the current ZIKV outbreak in the Americas. We highlight the urgent need for a coordinated collaborative response for prevention and spread of infectious diseases with epidemic potential at mass gatherings events.

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Reviews
HIV/AIDS: trends in the Middle East and North Africa region
Deniz Gökengin, Fardad Doroudi, Johnny Tohme, Ben Collins, Navid Madani
p66–73
Published in issue: March 2016
Highlights
:: New HIV infections have been on the rise in the Middle East and North Africa (MENA) region in recent years.
:: There is substantial heterogeneity in HIV epidemic dynamics across MENA, and different risk contexts are present throughout the region.
:: Overall, the major route of infection in the MENA region seems to be sexual transmission, but a range of challenges limit interventions to determine the actual sexual trends.
:: Despite unfavorable conditions, many countries in the region have put significant efforts into scaling up their response to this growing epidemic.
Summary
Objectives
To give an overview of the HIV epidemic in the Middle East and North Africa (MENA) region.
Methods
Articles on the MENA region were reviewed.
Results
The MENA region comprises a geographically defined group of countries including both high-income, well-developed nations and low- and middle-income countries. While the annual number of new HIV infections in Sub-Saharan Africa has declined by 33% since 2005, new HIV infections in the MENA region have increased by 31% since 2001, which is the highest increase among all regions in the world. Moreover, the number of AIDS-related deaths in 2013 was estimated to be 15 000, representing a 66% increase since 2005. However, the current prevalence of 0.1% is still among the lowest rates globally. There is substantial heterogeneity in HIV epidemic dynamics across MENA, and different risk contexts are present throughout the region. Despite unfavorable conditions, many countries in the region have put significant effort into scaling up their response to this growing epidemic, while in others the response to HIV is proving slower due to denial, stigma, and reluctance to address sensitive issues.
Conclusions
The HIV epidemic in the MENA region is still at a controllable level, and this opportunity should not be missed.

Immunization Policy and the Importance of Sustainable Vaccine Pricing

JAMA
March 8, 2016, Vol 315, No. 10
http://jama.jamanetwork.com/issue.aspx

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Viewpoint | March 8, 2016
The Ethical Challenges of Compassionate Use
FREE
Arthur L. Caplan, PhD; Amrit Ray, MD, MBA

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Viewpoint | March 8, 2016
Immunization Policy and the Importance of Sustainable Vaccine Pricing
H. Cody Meissner, MD1
[Initial text]
This Viewpoint discusses vaccine costs and policy and explains the importance of balancing these factors to provide optimal care while restricting spending on costly interventions with limited benefit.

The individual, societal, and economic benefits of disease prevention resulting from childhood and adult immunization programs in the United States are without question. A report from the Centers for Disease Control and Prevention (CDC) describing the benefits of vaccination of the 2009 birth cohort through 18 years of age estimated that 20 million cases of vaccine-preventable disease will not occur, 42 000 early deaths related to these diseases will be avoided, and $76 billion in direct and indirect costs will be averted.1 This economic benefit stands in stark contrast to the comparatively small cost for vaccine purchases. The estimated vaccine purchasing cost for a similar birth cohort based on 2015 pricing is $7.8 billion, based on CDC costs, and $11.6 billion at private sector pricing (eTable in the Supplement).2…

The Grand Divergence in Global Child Health Confronting Data Requirements in Areas of Conflict and Chronic Political Instability

JAMA Pediatrics
March 2016, Vol 170, No. 3
http://archpedi.jamanetwork.com/issue.aspx

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Editorial | March 2016
The Grand Divergence in Global Child Health Confronting Data Requirements in Areas of Conflict and Chronic Political Instability
FREE
Paul H. Wise, MD, MPH1,2; Gary L. Darmstadt, MD, MS1,2
Author Affiliations
1Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California
2Freeman Spogli Institute for International Studies, Stanford University, Stanford, California
[Initial text]
There is something deeply troubling about a death that goes unnoticed. Beyond the humane impulse to provide solace through collective acknowledgment and community support lies the recognition that an unnoticed death implies an unnoticed life. There can be no doubt that the accurate counting and causal attribution of morbidity and mortality provide technical information that is essential for public health planning, evaluation, and improvement in program performance. However, there is also a justice imperative inherent in counting and attribution—an imperative that transcends the practical and touches on the moral basis of global health and its commitment to the rights and societal claims of those whose health and well-being have for too long gone unnoticed.

At a global level, available data demonstrate that dramatic reductions in child mortality have occurred in many low- and middle-income countries. Moreover, long-standing disparities in survival between materially wealthy and poorer regions of the world are dissipating. If sustained, this historic record of reduced mortality inequality could drive a “grand convergence” in life expectancy during the next 2 decades.1 This prospect has been used constructively to advocate for a continued global commitment to economic development and the provision of effective health interventions.

On closer examination, however, it is apparent that the trends toward convergence have not been universal. Some countries are being left behind. These countries have experienced stagnant or, in some arenas, worsening child health outcomes. Indeed, these countries could be described as contributing to a “grand divergence” in life expectancies, in which their health indicators fall increasingly behind those of other low- and middle-income countries.2

The article by the Global Burden of Disease (GBD) Pediatrics Collaboration in this issue of JAMA Pediatrics represents an important contribution to the field of global health and provides troubling evidence of the diverging trends in child health and well-being.3 What is now evident from even a cursory examination of presented child mortality trends is that the countries making the least progress in child survival and well-being, particularly since 2000, are those most likely to be plagued by chronic civil conflict, political instability, and weak governance. Nigeria and the Democratic Republic of the Congo, which together account for more than a third of all child deaths in sub-Saharan Africa, experienced annual child mortality declines of 2.2% and 1.8%, respectively (eTable 9 in their Supplement). It is useful to note that during this same period among the most rapid annual declines were those recorded in China (6.01%), Iran (5.97%), and Bangladesh (5.24%).

Using data from the GBD 2013 study, the article presents detailed child mortality and morbidity trends for the 50 countries with the largest child and adolescent populations in the world, information that will prove essential for programmatic evaluation and planning…

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Special Communication
Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
FREE
Global Burden of Disease Pediatrics Collaboration
Includes: Supplemental Content
Abstract
Importance
The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce.
Objective
To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged Evidence Review
Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14,244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35,620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates.
Findings
Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905,059 deaths; 95% UI, 810 304-998,125), diarrheal diseases among older children (38,325 deaths; 95% UI, 30,365-47,678), and road injuries among adolescents (115186 deaths; 95% UI, 105 185-124870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world’s deaths from neonatal encephalopathy. Half of the world’s diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia.
Conclusions and Relevance
Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

The Lancet – Mar 12, 2016

The Lancet
Mar 12, 2016 Volume 387 Number 10023 p1027-1132
http://www.thelancet.com/journals/lancet/issue/current
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Editorial
The health crisis of mental health stigma
The Lancet
DOI: http://dx.doi.org/10.1016/S0140-6736(16)00687-5
Many people with mental illness experience shame, ostracism, and marginalisation due to their diagnosis, and often describe the consequences of mental health stigma as worse than those of the condition itself. Interventions to address stigma educate about mental illness and overcome the stereotypes that underlie prejudicial reactions. Along with pharmacological and psychological therapies, stigma interventions have emerged as potentially valuable and complementary tools.
In today’s Lancet, Graham Thornicroft and colleagues review the evidence for effectiveness of interventions to reduce mental health stigma and discrimination, and conclude that they can work at an individual and population level. The evidence of benefit was strongest for interventions involving an individual with lived experience of mental illness, with sustained commitment to delivery over a long period…

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Review
Evidence for effective interventions to reduce mental-health-related stigma and discrimination
Graham Thornicroft, Nisha Mehta, Sarah Clement, Sara Evans-Lacko, Mary Doherty, Diana Rose, Mirja Koschorke, Rahul Shidhaye, Claire O’Reilly, Claire Henderson
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00298-6
Summary
Stigma and discrimination in relation to mental illnesses have been described as having worse consequences than the conditions themselves. Most medical literature in this area of research has been descriptive and has focused on attitudes towards people with mental illness rather than on interventions to reduce stigma. In this narrative Review, we summarise what is known globally from published systematic reviews and primary data on effective interventions intended to reduce mental-illness-related stigma or discrimination. The main findings emerging from this narrative overview are that: (1) at the population level there is a fairly consistent pattern of short-term benefits for positive attitude change, and some lesser evidence for knowledge improvement; (2) for people with mental illness, some group-level anti-stigma inventions show promise and merit further assessment; (3) for specific target groups, such as students, social-contact-based interventions usually achieve short-term (but less clearly long-term) attitudinal improvements, and less often produce knowledge gains; (4) this is a heterogeneous field of study with few strong study designs with large sample sizes; (5) research from low-income and middle-income countries is conspicuous by its relative absence; (6) caution needs to be exercised in not overgeneralising lessons from one target group to another; (7) there is a clear need for studies with longer-term follow-up to assess whether initial gains are sustained or attenuated, and whether booster doses of the intervention are needed to maintain progress; (8) few studies in any part of the world have focused on either the service user’s perspective of stigma and discrimination or on the behaviour domain of behavioural change, either by people with or without mental illness in the complex processes of stigmatisation. We found that social contact is the most effective type of intervention to improve stigma-related knowledge and attitudes in the short term. However, the evidence for longer-term benefit of such social contact to reduce stigma is weak. In view of the magnitude of challenges that result from mental health stigma and discrimination, a concerted effort is needed to fund methodologically strong research that will provide robust evidence to support decisions on investment in interventions to reduce stigma.

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Comment
NextGen HIV prevention: new possibilities and questions
Kenneth H Mayer
Published Online: 04 March 2016
Summary
In less than a decade, HIV prevention has evolved from a reliance on education, behavioural interventions, and use of condoms to focusing on the optimum use of antiretrovirals to suppress infectiousness and for primary prophylaxis. Landmark studies have shown the efficacy of the early initiation of treatment for people infected with HIV,1 and the use of oral pre-exposure prophylaxis (PrEP) for those at highest risk to decrease HIV transmission.2 Despite PrEP being shown to be efficacious in most trials in which it was assessed, the paramount importance of consistent use of preventive medication was shown when oral and topical tenofovir-based regimens did not show efficacy in three studies involving young African women, primarily because of suboptimum adherence.