Partners In Health [to 12 September 2015]

Partners In Health [to 12 September 2015]
http://www.pih.org/blog

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Sep 10, 2015
“Guardian Angels” for Pregnant Women with HIV
Socios En Salud (SES), Partners In Health’s sister organization in Peru, understands the challenges pregnant women living with HIV face. SES launched a unique yearlong pilot program in which peer counselors—all of whom are HIV-positive themselves—contact expectant mothers and help them access the clinical and social services they need. Most importantly though, they are friends to women who feel completely alone following their diagnosis.

PATH [to 12 September 2015]

PATH [to 12 September 2015]
http://www.path.org/news/index.php

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Announcement
PATH joins leading global health organizations in calling for inclusion of research and development indicators in Sustainable Development Goal framework
Posted September 8, 2015.
As global leaders are set to adopt the Sustainable Development Goals (SDGs) later this month, PATH joined a group of leading global health organizations in commissioning a report that calls for the United Nations (UN) and its Member States to strengthen the SDG health targets by including indicators to measure global health research and development (R&D) progress. The report—Measuring global health R&D for the post-2015 development agenda—includes a short list of recommended global health R&D indicators for inclusion in the global and national SDG monitoring frameworks.

From the partner announcement:
The report underscores the critical link between global health R&D and achieving the SDGs. It notes that the SDGs include ambitious targets for reducing child and maternal deaths and ending the epidemics of HIV/AIDS, tuberculosis, malaria, and neglected tropical diseases, but existing global strategies that align with these targets clearly acknowledge they cannot be achieved without the development and delivery of new and improved drugs, vaccines, diagnostics, and other health tools. While the SDGs include a means of implementation target (target 3.b) to support R&D for vaccines and medicines for diseases primarily impacting developing countries, none of the official UN indicator proposals include any indicators to measure progress on the global health R&D needed to meet this and other health targets.

To fill this gap and ensure the SDGs generate the innovations needed to reach the health targets, the report proposes three indicators to measure global health R&D for inclusion in the SDG global monitoring framework, as well as five additional indicators countries are encouraged to include in their national monitoring frameworks if appropriate for their circumstances. These indicators were recommended based on an extensive landscaping and consultative process to identify health R&D indicators and further analysis to refine this list based on feasibility, level of community endorsement, appropriateness, and cross-cutting potential.

The report was prepared by Policy Cures and commissioned by the Council on Health Research for Development (COHRED), the Foundation for Innovative New Diagnostics (FIND), the Global Health Technologies Coalition (GHTC), the International AIDS Vaccine Initiative (IAVI), the Medicines for Malaria Venture (MMV), PATH, and the TB Alliance to inform stakeholders of the importance of including robust indicators for global health R&D and advise on the most suitable indicators for inclusion.

Plan International [to 12 September 2015]

Plan International [to 12 September 2015]
http://plan-international.org/about-plan/resources/media-centre

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Press releases
Europe must act together to save refugee children
11 September 2015
European leaders must urgently agree a comprehensive and united response to the arrival of thousands of refugees in European countries. In particular strenuous efforts must be made by all states across Europe to directly ensure refugee children and their families receive appropriate treatment, including food, shelter, sanitation, education, psychosocial support and protection from abuse…

SOS-Kinderdorf International [to 12 September 2015]

SOS-Kinderdorf International [to 12 September 2015]
http://www.sos-childrensvillages.org/about-sos/press/press-releases
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A global response to refugee crisis
11.09.2015 – SOS Children’s Villages International is continuing to respond in every possible way to the global humanitarian crisis of refugees and displaced people. Emergency response activities are underway in the Middle East and across Europe, bringing much needed relief to refugee children and their families.

CONCORD [to 12 September 2015]

CONCORD [to 12 September 2015]
European NGO confederation for relief and development
http://www.concordeurope.org/news-room

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The best and worst of Europe: CONCORD, Social Platform, EPAM statement on humanitarian crisis
(Brussels, 11/09/2015) In the face of the current humanitarian crisis affecting people fleeing war, persecution and poverty, EPAM, Social Platform and CONCORD Europe – the three largest coalitions of European NGOs working on development, social rights, asylum and migration – have come together to call on Member State governments and ministers to create a more welcoming Europe.

The Elders [to 12 September 2015]

The Elders [to 12 September 2015]
http://theelders.org/news-media

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Press release 7 September 2015
A stronger UN: The Elders hold high-level talks in Liechtenstein
As the UN celebrates its 70th year, three Elders travelled to Liechtenstein to participate in high-level discussions on strengthening the organisation with a distinguished and diverse group of experts

Vaduz – The Elders met in Liechtenstein on 5-6 September at the invitation of Foreign Minister Aurelia Frick to discuss proposals on strengthening the United Nations in its 70th anniversary year to ensure it remains “fit for purpose”.

Gro Harlem Brundtland, Deputy Chair of The Elders, led the delegation together with Lakhdar Brahimi and Martti Ahtisaari, and held wide-ranging discussions with ministers from Liechtenstein and other UN states, including several UN Permanent Representatives and former officials.

The discussions follow the launch of The Elders’ “Stronger UN” initiative at the Munich Security Conference in February 2015, which calls for four fundamental changes to the way the organisation operates: enlargement of the UN Security Council, a new agreement on UNSC veto restraint to prevent mass atrocities, a transparent and accountable mechanism to elect the new UN Secretary-General, and greater involvement of civil society in UN processes and decision-making…

Muslim Charities Forum [to 12 September 2015]

Muslim Charities Forum [to 12 September 2015]
https://www.muslimcharitiesforum.org.uk/media/news
[An umbrella organisation for Muslim-led international NGOs based in the UK. It was set up in 2007 and works to support its members through advocacy, training and research, by bringing charities together. Our members have a collective income of £150,000,000 and work in 71 countries.]

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Muslim Charities Forum Statement on the European Refugee Crisis
9th September 2015
More than 2000 refugees have drowned, losing their lives in a desperate attempt to reach Europe. Many of those victims have been women and children. Thousands more are stranded in southern and eastern Europe, desperate to build new lives after witnessing the horrors of war tear apart the fabric of their societies and homes.

So far, various European countries such as Germany, Sweden, & France have opened up their borders to allow in some of the refugees that have made it to the shores of Europe.

We welcome Prime Minister David Cameron’s pledge to allow in 20,000 refuges over the next five years but are dismayed at the comparatively low number in relation to some of our European neighbours. We are also disappointed by the fact that these refugees will only come from the camps neighbouring Syria. Whilst we commend all efforts to help those currently in the Middle East, the UK has a moral obligation to help the refugees that have made it to Europe, and to take its fair share of those refugees in a collective effort with others on the continent who are bearing the brunt of the crisis.

Though the focus has been on the Syrian refugees, we must not forget that many are also fleeing conflict, poverty and abuse from Iraq, Afghanistan, Eritrea, Nigeria, Somalia and other countries and need our help and compassion as well.

We ask that this government reconsider the number of refugees it will take in as well as shorten the time span to two years instead of five. We need immediate action now as this is a crisis situation. The UK needs to take a leadership role in this crisis due to its unique positioning in Europe and history in the region.

We also call upon our members to work together with local councils to support and resettle those that will be coming in, as well as coordinate their efforts with other NGOs who are already engaged with emergency relief in places like Calais, Greece, Macedonia and Hungary.

ODI [to 12 September 2015]

ODI [to 12 September 2015]
http://www.odi.org/media

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How does Nepal’s Child Grant work for Dalit children and their families?
Research reports and studies | September 2015 | Jessica Hagen-Zanker, Richard Mallett and Anita Ghimire
This study examines the delivery and impact of Nepal’s Child Grant to identify implementation barriers and recommend ways to improve effectiveness.

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Nepal’s Child Grant: how is it working for Dalit families?
Briefing papers | September 2015 | Jessica Hagen-Zanker and Richard Mallett
This briefing paper uses two case studies from Bajura and Saptari to identify issues with the current Child Grant programme in Nepal and provides recommendations for ways to improve its effectiveness.

Clinton Foundation [to 12 September 2015]

Clinton Foundation [to 12 September 2015]
https://www.clintonfoundation.org/press-releases-and-statements

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Press Release
No Ceilings Commemorates 20th Anniversary of Beijing Platform with Digital Awareness Campaign
8 Sept 2015Press Release
Campaign includes media partnership with MTV’s “Look Different” campaign to challenge bias and inspire action for a “No Ceilings generation”
Today, No Ceilings: The Full Participation Project, an initiative of the Clinton Foundation, launched a social media awareness effort to educate young Americans on the progress that has been made for girls and women worldwide, and gaps to full participation that still remain. This campaign will mark the 20th anniversary of the UN Fourth World Conference on Women and the Beijing Platform for Action, a turning point in the global agenda for gender equality…

HHMI – Howard Hughes Medical Institute [to 12 September 2015]

HHMI – Howard Hughes Medical Institute [to 12 September 2015]
https://www.hhmi.org/news

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Research [ September 8, 2015 ]
Stephen Elledge Receives Albert Lasker Basic Medical Research Award
HHMI Investigator Stephen Elledge of Brigham and Women’s Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.

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Science Education [ September 8, 2015 ]
WildCam Gorongosa: Help Tag Animal Selfies to Support Conservation in Africa
HHMI and the Zooniverse launch WildCam Gorongosa, a new citizen science project.

MacArthur Foundation [to 12 September 2015]

MacArthur Foundation [to 12 September 2015]
http://www.macfound.org/

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Publication
September 9, 2015
A Landscape Evaluation of Oil Governance in Uganda and Kenya
…A key output of the study was the creation of a framework to monitor and evaluate both the impact of the oil sector on the environmental and socioeconomic livelihoods of people. It is available in the report available for download and includes an analysis of the robustness of existing data that the Foundation and others might track, or work to improve, in order to better understand the pace and kind of changes taking place. The report also contains specific recommendations related to Uganda and Kenya made by UNEP-WCMC.
Download the complete evaluation

Gordon and Betty Moore Foundation [to 12 September 2015]

Gordon and Betty Moore Foundation [to 12 September 2015]
https://www.moore.org/newsroom/press-releases

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Fourth wheat gene is key to flowering and climate adaptation
September 4, 2015
In the game of wheat genetics, Jorge Dubcovsky’s laboratory at UC Davis has hit a grand slam, unveiling for the fourth time in a dozen years a gene that governs wheat vernalization, the biological process requiring cold temperatures to trigger flower formation.

Maternal health care use among married women in Hossaina, Ethiopia

BMC Health Services Research
http://www.biomedcentral.com/bmchealthservres/content
(Accessed 12 September 2015)

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Research article
Maternal health care use among married women in Hossaina, Ethiopia
Zeleke Dutamo, Nega Assefa, Gudina Egata BMC Health Services Research 2015, 15:365 (10 September 2015)
Abstract
Background
Pregnancy and child birth are natural process of continuity of life. For many it is a normal process, for some it puts life at risk impending complications. Provision of skilled care for all women before, during, and after childbirth is a key in saving women’s life and ensuring delivery of healthy baby. Maternal health service drop-out through the course of pregnancy is widely claimed, yet by how much it is dropped is not known. The main aim of this study was to identify the use of maternal health service over the course of pregnancy and child birth in a comprehensive manner.
Methods
A community based cross-sectional quantitative study on 623 women supported by qualitative inquiry was conducted Hossaian town, South Ethiopia during January 1–31, 2014. A structured questionnaire was used to generate the quantitative data and 4 Focus Group Discussions (FGD) were carried out to support the finding. Multiple logistic regression was used to control the effect of confounding. Odds ratios with 95 % CI used to display the result of analysis. Data generated from the FGD was analyzed using thematic analysis.
Results
The study revealed that 87.6 % of women attended at least one antenatal care (ANC). Among 546 women who attended ANC, 61.3 % of the women made their first visit during second and third trimester of pregnancy and 49 % had less than four antenatal visits. The study also revealed that 62.6 % of deliveries were assisted by skilled attendants and 51.4 % of the women received at least one postnatal check-up. Parity, pregnancy intention and awareness on danger signs of pregnancy during pregnancy were significantly associated (p < 0.05) with ANC usage. Skilled delivery attendance was significantly associated with some socio-demographic, economic and obstetric factors. Average family monthly income, awareness on obstetric danger signs of pregnancy during recent pregnancy, and frequency of ANC were positive predictors of Postnatal Care (PNC) utilization.
Conclusions
Though use of maternal health care services is relatively higher, however, it is not adequate. Engaging women in their own reproductive health affairs, strengthening maternal health care, increasing community awareness about obstetric danger signs during pregnancy and child birth, and telling the benefit of family planning should be major targets for intervention.

BMC Medical Ethics (Accessed 12 September 2015)

BMC Medical Ethics
http://www.biomedcentral.com/bmcmedethics/content
(Accessed 12 September 2015)

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Debate
Informed consent in paediatric critical care research – a South African perspective
Brenda Morrow, Andrew Argent, Sharon Kling BMC Medical Ethics 2015, 16:62 (9 September 2015)
Abstract
Background
Medical care of critically ill and injured infants and children globally should be based on best research evidence to ensure safe, efficacious treatment. In South Africa and other low and middle-income countries, research is needed to optimise care and ensure rational, equitable allocation of scare paediatric critical care resources.
Ethical oversight is essential for safe, appropriate research conduct. Informed consent by the parent or legal guardian is usually required for child research participation, but obtaining consent may be challenging in paediatric critical care research. Local regulations may also impede important research if overly restrictive.
By narratively synthesising and contextualising the results of a comprehensive literature review, this paper describes ethical principles and regulations; potential barriers to obtaining prospective informed consent; and consent options in the context of paediatric critical care research in South Africa.
Discussion
Voluntary prospective informed consent from a parent or legal guardian is a statutory requirement for child research participation in South Africa. However, parents of critically ill or injured children might be incapable of or unwilling to provide the level of consent required to uphold the ethical principle of autonomy. In emergency care research it may not be practical to obtain consent when urgent action is required. Therapeutic misconceptions and sociocultural and language issues are also barriers to obtaining valid consent.
Alternative consent options for paediatric critical care research include a waiver or deferred consent for minimal risk and/or emergency research, whilst prospective informed consent is appropriate for randomised trials of novel therapies or devices.
Summary
We propose that parents or legal guardians of critically ill or injured children should only be approached to consent for their child’s participation in clinical research when it is ethically justifiable and in the best interests of both child participant and parent. Where appropriate, alternatives to prospective informed consent should be considered to ensure that important paediatric critical care research can be undertaken in South Africa, whilst being cognisant of research risk. This document could provide a basis for debate on consent options in paediatric critical care research and contribute to efforts to advocate for South African law reform.

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Debate
Obligations of low income countries in ensuring equity in global health financing
John Barugahare, Reidar Lie BMC Medical Ethics 2015, 16:59 (8 September 2015)
Abstract
Background
Despite common recognition of joint responsibility for global health by all countries particularly to ensure justice in global health, current discussions of countries’ obligations for global health largely ignore obligations of developing countries. This is especially the case with regards to obligations relating to health financing. Bearing in mind that it is not possible to achieve justice in global health without achieving equity in health financing at both domestic and global levels, our aim is to show how fulfilling the obligation we propose will make it easy to achieve equity in health financing at both domestic and international levels.
Discussion
Achieving equity in global health financing is a crucial step towards achieving justice in global health. Our general view is that current discussions on global health equity largely ignore obligations of Low Income Country (LIC) governments and we recommend that these obligations should be mainstreamed in current discussions. While we recognise that various obligations need to be fulfilled in order to ultimately achieve justice in global health, for lack of space we prioritise obligations for health financing. Basing on the evidence that in most LICs health is not given priority in annual budget allocations, we propose that LIC governments should bear an obligation to allocate a certain minimum percent of their annual domestic budget resources to health, while they await external resources to supplement domestic ones. We recommend and demonstrate a mechanism for coordinating this obligation so that if the resulting obligations are fulfilled by both LIC and HIC governments it will be easy to achieve equity in global health financing.
Summary
Although achieving justice in global health will depend on fulfilment of different categories of obligations, ensuring inter- and intra-country equity in health financing is pivotal. This can be achieved by requiring all LIC governments to allocate a certain optimal per cent of their domestic budget resources to health while they await external resources to top up in order to cover the whole cost of the minimum health opportunities for LIC citizens.

Reasons for home delivery and use of traditional birth attendants in rural Zambia: a qualitative study

BMC Pregnancy and Childbirth
http://www.biomedcentral.com/bmcpregnancychildbirth/content
(Accessed 12 September 2015)

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Research article
Reasons for home delivery and use of traditional birth attendants in rural Zambia: a qualitative study
Cephas Sialubanje, Karlijn Massar, Davidson Hamer, Robert Ruiter BMC Pregnancy and Childbirth 2015, 15:216 (11 September 2015)
Abstract
Background
Despite the policy change stopping traditional birth attendants (TBAs) from conducting deliveries at home and encouraging all women to give birth at the clinic under skilled care, many women still give birth at home and TBAs are essential providers of obstetric care in rural Zambia. The main reasons for pregnant women’s preference for TBAs are not well understood. This qualitative study aimed to identify reasons motivating women to giving birth at home and seek the help of TBAs. This knowledge is important for the design of public health interventions focusing on promoting facility-based skilled birth attendance in Zambia.
Methods
We conducted ten focus group discussions (n = 100) with women of reproductive age (15–45 years) in five health centre catchment areas with the lowest institutional delivery rates in the district. In addition, a total of 30 in-depth interviews were conducted comprising 5 TBAs, 4 headmen, 4 husbands, 4 mothers, 4 neighbourhood health committee (NHC) members, 4 community health workers (CHWs) and 5 nurses. Perspectives on TBAs, the decision-making process regarding home delivery and use of TBAs, and reasons for preference of TBAs and their services were explored.
Results
Our findings show that women’s lack of decision- making autonomy regarding child birth, dependence on the husband and other family members for the final decision, and various physical and socioeconomic barriers including long distances, lack of money for transport and the requirement to bring baby clothes and food while staying at the clinic, prevented them from delivering at a clinic. In addition, socio-cultural norms regarding childbirth, negative attitude towards the quality of services provided at the clinic, made most women deliver at home. Moreover, most women had a positive attitude towards TBAs and perceived them to be respectful, skilled, friendly, trustworthy, and available when they needed them.
Conclusion
Our findings suggest a need to empower women with decision-making skills regarding childbirth and to lower barriers that prevent them from going to the health facility in time. There is also need to improve the quality of existing facility-based delivery services and to strengthen linkages between TBAs and the formal health system.

BMC Public Health (Accessed 12 September 2015)

BMC Public Health
http://www.biomedcentral.com/bmcpublichealth/content
(Accessed 12 September 2015)

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Research article
Implementation of an HPV vaccination program in Eldoret, Kenya: results from a qualitative assessment by key stakeholders
Heleen Vermandere, Violet Naanyu, Olivier Degomme, Kristien Michielsen BMC Public Health 2015, 15:875 (10 September 2015)
Abstract
Background
Cervical cancer strikes hard in low-resource regions yet primary prevention is still rare. Pilot projects have however showed that Human Papillomavirus (HPV) vaccination programs can attain high uptake. Nevertheless, a study accompanying a vaccination demonstration project in Eldoret, Kenya, revealed less encouraging outcomes: uptake during an initial phase targeting ten schools (i.e., 4000 eligible girls), was low and more schools had to be included to reach the proposed number of 3000 vaccinated girls. The previously conducted study also revealed that many mothers had not received promotional information which had to reach them through schools: teachers were sensitized by health staff and asked to invite students and parents for HPV vaccination in the referral hospital. In this qualitative study, we investigate factors that hampered promotion and vaccine uptake.
Methods
Focus group discussions (FGD) with teachers (4) and fathers (3) were organized to assess awareness and attitudes towards the vaccination program, cervical cancer and the HPV vaccine, as well as a FGD with the vaccinators (1) to discuss the course of the program and potential improvements. Discussions were recorded, transcribed, translated, and analyzed using thematic analysis In addition, a meeting with the program coordinator was set up to reflect upon the program and the results of the FGD, and to formulate recommendations for future programs.
Results
Cervical cancer was poorly understood by fathers and teachers and mainly linked with nonconforming sexual behavior and modern lifestyle. Few had heard about the vaccination opportunity: feeling uncomfortable to discuss cervical cancer and not considering it as important had hampered information flow. Teachers requested more support from health staff to address unexpected questions from parents. Non-uptake was also the result of distrust towards new vaccines. Schools entering the program in the second phase reacted faster: they were better organized, e.g., in terms of transport, while the community was already more familiarized with the vaccine.
Conclusions
Close collaboration between teachers and health staff is crucial to obtain high HPV vaccine uptake among schoolgirls. Promotional messages should, besides providing correct information, tackle misbeliefs, address stigma and stress the priority to vaccinate all, regardless of lifestyle. Monitoring activities and continuous communication could allow for detection of rumors and unequal uptake in the community.

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Debate
Strategies to increase demand for maternal health services in resource-limited settings: challenges to be addressed
Khalifa Elmusharaf, Elaine Byrne, Diarmuid O’Donovan BMC Public Health 2015, 15:870 (8 September 2015)
Abstract
Background
Universal health access will not be achieved unless women are cared for in their own communities and are empowered to take decisions about their own health in a supportive environment. This will only be achieved by community-based demand side interventions for maternal health access. In this review article, we highlight three common strategies to increase demand-side barriers to maternal healthcare access and identify the main challenges that still need to be addressed for these strategies to be effective.
Discussion
Common demand side strategies can be grouped into three categories:(i) Financial incentives/subsidies; (ii) Enhancing patient transfer, and; (iii) Community involvement. The main challenges in assessing the effectiveness or efficacy of these interventions or strategies are the lack of quality evidence on their outcome and impact and interventions not integrated into existing health or community systems. However, what is highlighted in this review and overlooked in most of the published literature on this topic is the lack of knowledge about the context in which these strategies are to be implemented.
Summary
We suggest three challenges that need to be addressed to create a supportive environment in which these demand-side strategies can effectively improve access to maternal health services. These include: addressing decision-making norms, engaging in intergenerational dialogue, and designing contextually appropriate communication strategies.

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Research article
Women’s position and attitudes towards female genital mutilation in Egypt: A secondary analysis of the Egypt demographic and health surveys, 1995-2014
Ronan Van Rossem, Dominique Meekers, Anastasia Gage BMC Public Health 2015, 15:874 (10 September 2015
Abstract
Background
Female genital mutilation (FGM) is still widespread in Egyptian society. It is strongly entrenched in local tradition and culture and has a strong link to the position of women. To eradicate the practice a major attitudinal change is a required for which an improvement in the social position of women is a prerequisite. This study examines the relationship between Egyptian women’s social positions and their attitudes towards FGM, and investigates whether the spread of anti-FGM attitudes is related to the observed improvements in the position of women over time.
Methods
Changes in attitudes towards FGM are tracked using data from the Egypt Demographic and Health Surveys from 1995 to 2014. Multilevel logistic regressions are used to estimate 1) the effects of indicators of a woman’s social position on her attitude towards FGM, and 2) whether these effects change over time.
Results
Literate, better educated and employed women are more likely to oppose FGM. Initially growing opposition to FGM was related to the expansion of women’s education, but lately opposition to FGM also seems to have spread to other segments of Egyptian society.
Conclusions
The improvement of women’s social position has certainly contributed to the spread of anti-FGM attitudes in Egyptian society. Better educated and less traditional women were at the heart of this change, and formed the basis from where anti-FGM sentiment has spread over wider segments of Egyptian society.

British Medical Journal – 28 August 2015

British Medical Journal
28 August 2015 (vol 351, issue 8024)
http://www.bmj.com/content/351/8024

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Editorials
Europe’s refugee crisis: an urgent call for moral leadership
BMJ 2015; 351 doi: http://dx.doi.org/10.1136/bmj.h4833 (Published 09 September 2015) Cite this as: BMJ 2015;351:h4833
Kamran Abbasi, international editor, The BMJ,
Kiran Patel, consultant cardiologist, Heart of England NHS Trust,
Fiona Godlee, editor in chief, The BMJ
Offering asylum is a minimum standard of civilised society
Europe’s refugee crisis is the greatest test of humanity faced by the world’s rich countries this century. It isn’t a new crisis. Nor was it difficult for politicians to anticipate. Refugees have fled to Europe since at least the premature optimism of the Arab Spring in 2011. Today, optimism is replaced by desperation, a promise of freedom overshadowed by death. Western nations rushed to support the democratic principles of the Arab Spring yet are reluctant to address the root causes and the consequences, which include civil war and state brutality, most notably in Syria. Oil rich Arab States have played their part by allowing political oppression and conflict to flourish in their region. A funding crisis in UN organisations is affecting the humanitarian effort in the Middle East, driving refugees to Europe in greater numbers.1 Ignoring injustice and inequity in poorer countries and in areas of conflict has not prevented the consequences reaching the shores and borders of the rich world…

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Research
Effect of bivalent human papillomavirus vaccination on pregnancy outcomes: long term observational follow-up in the Costa Rica HPV Vaccine Trial
BMJ 2015; 351 doi: http://dx.doi.org/10.1136/bmj.h4358 (Published 07 September 2015) Cite this as: BMJ 2015;351:h4358
Orestis A Panagiotou, researcher1, Brian L Befano, senior programmer2, Paula Gonzalez, investigator34, Ana Cecilia Rodríguez, investigator3, Rolando Herrero, group head4, John T Schiller, senior investigator5, Aimée R Kreimer, investigator1, Mark Schiffman, senior investigator1, Allan Hildesheim, senior investigator1, Allen J Wilcox, senior investigator6, Sholom Wacholder, senior investigator1 on behalf of the Costa Rica HPV Vaccine Trial (CVT) Group (see end of manuscript for full list of investigators)
Abstract
Objective
To examine the effect of the bivalent human papillomavirus (HPV) vaccine on miscarriage.
Design
Observational long term follow-up of a randomized, double blinded trial combined with an independent unvaccinated population based cohort.
Setting S
ingle center study in Costa Rica.
Participants
7466 women in the trial and 2836 women in the unvaccinated cohort enrolled at the end of the randomized trial and in parallel with the observational trial component.
Intervention Women in the trial were assigned to receive three doses of bivalent HPV vaccine (n=3727) or the control hepatitis A vaccine (n=3739). Crossover bivalent HPV vaccination occurred in the hepatitis A vaccine arm at the end of the trial. Women in the unvaccinated cohort received (n=2836) no vaccination.
Main outcome measure
Risk of miscarriage, defined by the US Centers for Disease Control and Prevention as fetal loss within 20 weeks of gestation, in pregnancies exposed to bivalent HPV vaccination in less than 90 days and any time from vaccination compared with pregnancies exposed to hepatitis A vaccine and pregnancies in the unvaccinated cohort.
Results
Of 3394 pregnancies conceived at any time since bivalent HPV vaccination, 381 pregnancies were conceived less than 90 days from vaccination. Unexposed pregnancies comprised 2507 pregnancies conceived after hepatitis A vaccination and 720 conceived in the unvaccinated cohort. Miscarriages occurred in 451 (13.3%) of all exposed pregnancies, in 50 (13.1%) of the pregnancies conceived less than 90 days from bivalent HPV vaccination, and in 414 (12.8%) of the unexposed pregnancies, of which 316 (12.6%) were in the hepatitis A vaccine group and 98 (13.6%) in the unvaccinated cohort. The relative risk of miscarriage for pregnancies conceived less than 90 days from vaccination compared with all unexposed pregnancies was 1.02 (95% confidence interval 0.78 to 1.34, one sided P=0.436) in unadjusted analyses. Results were similar after adjusting for age at vaccination (relative risk 1.15, one sided P=0.17), age at conception (1.03, P=0.422), and calendar year (1.06, P=0.358), and in stratified analyses. Among pregnancies conceived at any time from bivalent HPV vaccination, exposure was not associated with an increased risk of miscarriage overall or in subgroups, except for miscarriages at weeks 13-20 of gestation (relative risk 1.35, 95% confidence interval 1.02 to 1.77, one sided P=0.017).
Conclusions
There is no evidence that bivalent HPV vaccination affects the risk of miscarriage for pregnancies conceived less than 90 days from vaccination. The increased risk estimate for miscarriages in a subgroup of pregnancies conceived any time after vaccination may be an artifact of a thorough set of sensitivity analyses, but since a genuine association cannot totally be ruled out, this signal should nevertheless be explored further in existing and future studies.
Trial registration
Clinicaltrials.gov NCT00128661 and NCT01086709.

Health Affairs – Issue Theme: Noncommunicable Diseases: The Growing Burden

Health Affairs
September 2015; Volume 34, Issue 9
http://content.healthaffairs.org/content/current

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Issue Theme: Noncommunicable Diseases: The Growing Burden
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Achieving Effective Universal Health Coverage And Diagonal Approaches To Care For Chronic Illnesses
Felicia Marie Knaul1,*, Afsan Bhadelia2, Rifat Atun3 and Julio Frenk4
Author Affiliations
1Felicia Marie Knaul (fknaul@gmail.com) is director of the Miami Institute for the Americas and professor at the Miller School of Medicine, University of Miami, in Florida. At the time this research was conducted, she was director of the Harvard Global Equity Initiative, in Boston, Massachusetts.
2Afsan Bhadelia is a research associate at the Harvard Global Equity Initiative.
3Rifat Atun is a professor of global health systems in the Department of Global Health and Population at the Harvard School of Public Health.
4Julio Frenk is president of the University of Miami, in Florida. At the time this research was conducted, he was dean of the Harvard School of Public Health.
*Corresponding author
Abstract
Health systems in low- and middle-income countries were designed to provide episodic care for acute conditions. However, the burden of disease has shifted to be overwhelmingly dominated by chronic conditions and illnesses that require health systems to function in an integrated manner across a spectrum of disease stages from prevention to palliation. Low- and middle-income countries are also aiming to ensure health care access for all through universal health coverage. This article proposes a framework of effective universal health coverage intended to meet the challenge of chronic illnesses. It outlines strategies to strengthen health systems through a “diagonal approach.” We argue that the core challenge to health systems is chronicity of illness that requires ongoing and long-term health care. The example of breast cancer within the broader context of health system reform in Mexico is presented to illustrate effective universal health coverage along the chronic disease continuum and across health systems functions. The article concludes with recommendations to strengthen health systems in order to achieve effective universal health coverage.

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Cardiovascular Disease Screening By Community Health Workers Can Be Cost-Effective In Low-Resource Countries
Thomas Gaziano1,*, Shafika Abrahams-Gessel2, Sam Surka3, Stephen Sy4, Ankur Pandya5,
Catalina A. Denman6, Carlos Mendoza7, Thandi Puoane8 and Naomi S. Levitt9
Author Affiliations
1Thomas Gaziano (tgaziano@partners.org) is an assistant professor in the Cardiovascular Division of Brigham and Women’s Hospital, in Boston, Massachusetts.
2Shafika Abrahams-Gessel is a research manager at the Center for Health Decision Science in the Harvard T. H. Chan School of Public Health, in Boston.
3Sam Surka is a researcher in the Chronic Diseases Initiative for Africa at Old Groote Schuur Hospital, in Cape Town, South Africa.
4Stephen Sy is a programmer at the Center for Health Decision Science in the Harvard T. H. Chan School of Public Health.
5Ankur Pandya is an assistant professor of health policy and management at the Harvard T. H. Chan School of Public Health.
6Catalina A. Denman is a professor in the Centro de Estudios en Salud y Sociedad at El Colegio de Sonora, in Hermosillo, Mexico.
7Carlos Mendoza is a coinvestigator at the Instituto de Nutricion de Centro America y Panama, in Guatemala City, Guatemala.
8Thandi Puoane is a professor in the School of Public Health at the University of the Western Cape, in Bellville, South Africa.
9Naomi S. Levitt is director of the Division of Diabetes and the Chronic Diseases Initiative for Africa, both at Old Groote Schuur Hospital.
*Corresponding author
Abstract
In low-resource settings, a physician is not always available. We recently demonstrated that community health workers—instead of physicians or nurses—can efficiently screen adults for cardiovascular disease in South Africa, Mexico, and Guatemala. In this analysis we sought to determine the health and economic impacts of shifting this screening to community health workers equipped with either a paper-based or a mobile phone–based screening tool. We found that screening by community health workers was very cost-effective or even cost-saving in all three countries, compared to the usual clinic-based screening. The mobile application emerged as the most cost-effective strategy because it could save more lives than the paper tool at minimal extra cost. Our modeling indicated that screening by community health workers, combined with improved treatment rates, would increase the number of deaths averted from 15,000 to 110,000, compared to standard care. Policy makers should promote greater acceptance of community health workers by both national populations and health professionals and should increase their commitment to treating cardiovascular disease and making medications available.

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Overcoming Obstacles To Enable Access To Medicines For Noncommunicable Diseases In Poor Countries
Sandeep P. Kishore1,*, Kavitha Kolappa2, Jordan D. Jarvis3, Paul H. Park4, Rachel Belt5,
Thirukumaran Balasubramaniam6 and Rachel Kiddell-Monroe7
Author Affiliations
1Sandeep P. Kishore (sunny.kishore@gmail.com) is a fellow at Yale University, in New Haven, Connecticut, and president of the Young Professionals Chronic Disease Network, in Boston, Massachusetts.
2Kavitha Kolappa is a resident in psychiatry at Massachusetts General Hospital, in Boston, a and board member for the Young Professionals Chronic Disease Network.
3Jordan D. Jarvis is executive director of the Young Professionals Chronic Disease Network and a former postgraduate research fellow at the Harvard Global Equity Initiative, in Boston.
4Paul H. Park is director of noncommunicable diseases for Partners in Health—Rwanda and a member of Universities Allied for Essential Medicines, in Washington, D.C.
5Rachel Belt is a member of Universities Allied for Essential Medicines.
6Thirukumaran Balasubramaniam is a Geneva representative at Knowledge Ecology International, in Switzerland.
7Rachel Kiddell-Monroe is a special adviser for the Universities Allied for Essential Medicines, a board member for the Young Professionals Chronic Disease Network, and a member of the International Board for Médecins sans Frontières, in Geneva.
*Corresponding author
Abstract
The modern access-to-medicines movement grew largely out of the civil-society reaction to the HIV/AIDS pandemic three decades ago. While the movement was successful with regard to HIV/AIDS medications, the increasingly urgent challenge to address access to medicines for noncommunicable diseases has lagged behind—and, in some cases, has been forgotten. In this article we first ask what causes the access gap with respect to lifesaving essential noncommunicable disease medicines and then what can be done to close the gap. Using the example of the push for access to antiretrovirals for HIV/AIDS patients for comparison, we highlight the problems of inadequate global financing and procurement for noncommunicable disease medications, intellectual property barriers and concerns raised by the pharmaceutical industry, and challenges to building stronger civil-society organizations and a patient and humanitarian response from the bottom up to demand treatment. We provide targeted policy recommendations, specific to the public sector, the private sector, and civil society, with the goal of improving access to noncommunicable disease medications globally.

International Journal of Infectious Diseases – September 2015

International Journal of Infectious Diseases
September 2015 Volume 38, In Progress
http://www.ijidonline.com/current

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Planning for the Next Global Pandemic
Allen G.P. Ross, Suzanne M. Crowe, Mark W. Tyndall
Corresponding Editor: Eskild Petersen, Aarhus, Denmark
DOI: http://dx.doi.org/10.1016/j.ijid.2015.07.016
Abstract
In order to mitigate human and financial losses as a result of future global pandemics, we must plan now. As the Ebola virus pandemic declines, we must reflect on how we have mismanaged this recent international crisis and how we can better prepare for the next global pandemic. Of great concern is the increasing frequency of pandemics occurring over the last few decades. Clearly, the window of opportunity to act is closing. This editorial discusses many issues including priority emerging and re-emerging infectious diseases; the challenges of meeting international health regulations; the strengthening of global health systems; global pandemic funding; and the One Health approach to future pandemic planning. We recommend that the global health community unites to urgently address these issues in order to avoid the next humanitarian crisis.

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Short Communications
Investigating the immunizing effect of the rubella epidemic in Japan, 2012-14
Hiroshi Nishiura, Ryo Kinoshita, Yuichiro Miyamatsu, Kenji Mizumoto
p16–18
Published online: July 13 2015

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Epidemiological features and trends of Ebola virus disease in West Africa
Ligui Wang, Guang Yang, Leili Jia, Zhenjun Li, Jing Xie, Peng Li, Shaofu Qiu, Rongzhang Hao, Zhihao Wu, Hui Ma, Hongbin Song
p52–53
Published online: July 24 2015

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Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea
Shui Shan Lee, Ngai Sze Wong
p65–67