Nature
Volume 527 Number 7578 pp275-404 19 November 2015
http://www.nature.com/nature/current_issue.html

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Comment
Sustainability: Transfer project cannot meet China’s water needs
Better local water management is the way to keep pace with escalating demands, not pumping water across the country, warn Jon Barnett and colleagues.

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Nature | Supplement Open
Global research challenges and opportunities for mental health and substance-use disorders
Florence Baingana, Mustafa al’Absi, Anne E. Becker & Beverly Pringle
Affiliations
Corresponding author
Nature 527, S172–S177 (19 November 2015)
doi:10.1038/nature16032
Published online 18 November 2015
Abstract
The research agenda for global mental health and substance-use disorders has been largely driven by the exigencies of high health burdens and associated unmet needs in low- and middle-income countries. Implementation research focused on context-driven adaptation and innovation in service delivery has begun to yield promising results that are improving the quality of, and access to, care in low-resource settings. Importantly, these efforts have also resulted in the development and augmentation of local, in-country research capacities. Given the complex interplay between mental health and substance-use disorders, medical conditions, and biological and social vulnerabilities, a revitalized research agenda must encompass both local variation and global commonalities in the impact of adversities, multi-morbidities and their consequences across the life course. We recommend priorities for research — as well as guiding principles for context-driven, intersectoral, integrative approaches — that will advance knowledge and answer the most pressing local and global mental health questions and needs, while also promoting a health equity agenda and extending the quality, reach and impact of scientific enquiry